Tilorone

Modify Date: 2024-01-04 21:12:50

Tilorone structure	Common Name	Tilorone
	CAS Number	27591-97-5	Molecular Weight	410.549
	Density	1.1±0.1 g/cm3	Boiling Point	552.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₃₄N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	287.8±30.1 °C

Name	2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	552.3±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₄N₂O₃
Molecular Weight	410.549
Flash Point	287.8±30.1 °C
Exact Mass	410.256958
PSA	42.01000
LogP	5.25
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.564
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL8990000

CHEMICAL NAME :: 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-

CAS REGISTRY NUMBER :: 27591-97-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C25-H34-N2-O3

MOLECULAR WEIGHT :: 410.61

WISWESSER LINE NOTATION :: L B656 HVJ EO2N2&2 KO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Immunological Including Allergic - increased immune response Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 11,91,1975

Tilorone dihydrochloride structure

Tilorone dihydr...

CAS#:27591-69-1

~82%

Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Schulze; Letsch; Gutsche; et al. Pharmazie, 1984 , vol. 39, # 5 p. 320 - 322

2,7-Dihydroxy-9-fluorenone structure

2,7-Dihydroxy-9...

CAS#:42523-29-5

2-Diethylaminoethylchloride Hydrochloride structure

2-Diethylaminoe...

CAS#:869-24-9

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Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

(7-acetyloxy-9-oxofluoren-2-yl) acetate structure

(7-acetyloxy-9-...

CAS#:53133-99-6

2-Diethylaminoethylchloride Hydrochloride structure

2-Diethylaminoe...

CAS#:869-24-9

~%

Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

methyl 4,4'-bis(2-(diethylamino)ethoxy)-[1,1'-biphenyl]-2-carboxylate structure

methyl 4,4'-bis...

CAS#:1010786-65-8

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Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611

2,7-Dinitro-9H-fluoren-9-one structure

2,7-Dinitro-9H-...

CAS#:31551-45-8

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Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

acetic acid,9H-fluorene-2,7-diol structure

acetic acid,9H-...

CAS#:53134-09-1

~%

Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

9H-Fluoren-9-one,2,7-diamino- structure

9H-Fluoren-9-on...

CAS#:2915-84-6

~%

Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

2-(Diethylamino)ethanol structure

2-(Diethylamino...

CAS#:100-37-8

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Tilorone Structure

Tilorone

CAS#:27591-97-5

Literature: Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450

UNII-O6W7VEW6KS

Tilorone

Amixin IC

2,7-Bis-DEAE-fluorenone

Tilorone base

Tilorone hydrochloride

2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one

9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-

Bis-DEAE-fluorenone

9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-

L B656 HVJ EO2N2&2 KO2N2&2