Tilorone dihydrochloride

Modify Date: 2024-01-02 10:43:26

Tilorone dihydrochloride structure	Common Name	Tilorone dihydrochloride
	CAS Number	27591-69-1	Molecular Weight	483.471
	Density	1.102g/cm3	Boiling Point	552.3ºC at 760 mmHg
	Molecular Formula	C₂₅H₃₆Cl₂N₂O₃	Melting Point	230-233 °C(lit.)
	MSDS	Chinese USA	Flash Point	287.8ºC
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Tilorone dihydrochloride

Tilorone dihydrochloride is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer, used as an antiviral drug.

Name	Tilorone dihydrochloride
Synonym	More Synonyms

Description	Tilorone dihydrochloride is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer, used as an antiviral drug.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Infection

Density	1.102g/cm3
Boiling Point	552.3ºC at 760 mmHg
Melting Point	230-233 °C(lit.)
Molecular Formula	C₂₅H₃₆Cl₂N₂O₃
Molecular Weight	483.471
Flash Point	287.8ºC
Exact Mass	482.210297
PSA	42.01000
LogP	5.94320
Vapour Pressure	3.05E-12mmHg at 25°C

Tilorone dihydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL9000000

CHEMICAL NAME :: Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride

CAS REGISTRY NUMBER :: 27591-69-1

LAST UPDATED :: 199606

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C25-H34-N2-O3.2Cl-H

MOLECULAR WEIGHT :: 483.53

WISWESSER LINE NOTATION :: L B656 HVJ EO2N2&2 LO2N2&2 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 852 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 150 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 28,5,1972 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335-H351
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R20/21/22;R36/37/38;R40
Safety Phrases	S7-S22-S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LL9000000
HS Code	2922509090

Tilorone

CAS#:27591-97-5

~87%

Tilorone dihydr...

CAS#:27591-69-1

Literature: Chernyshev, Vladimir V.; Yatsenko, Alexandr V.; Pirogov, Sergey V.; Nikulenkova, Tamara F.; Tumanova, Ekaterina V.; Lonin, Ivan S.; Paseshnichenko, Ksenia A.; Mironov, Andrei V.; Velikodny, Yurii A. Crystal Growth and Design, 2012 , vol. 12, # 12 p. 6118 - 6125

2-Diethylaminoe...

CAS#:869-24-9

Tilorone dihydr...

CAS#:27591-69-1

Literature: Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450

2-(Diethylamino...

CAS#:100-37-8

Tilorone dihydr...

CAS#:27591-69-1

Literature: Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450

Tilorone

CAS#:27591-97-5

Isopropanol

CAS#:67-63-0

Tilorone dihydr...

CAS#:27591-69-1

Literature: Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450

Precursor 4
CAS#:27591-97-5 Tilorone CAS#:869-24-9 2-Diethylaminoe... CAS#:100-37-8 2-(Diethylamino... CAS#:67-63-0 Isopropanol
DownStream 2
CAS#:27591-97-5 Tilorone CAS#:93418-47-4 2-[7-[2-(diethy...

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose.

Pharmazie 68(10) , 796-9, (2013)

The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matri...

SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

Bioorg. Med. Chem. Lett. 22 , 1633-8, (2012)

The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the α7 neuronal nicotinic receptor (K(i)=56 nM). SAR investigations determined that both basic s...

Discovery of inhibitors of Bacillus anthracis primase DnaG.

Biochemistry 52(39) , 6905-10, (2013)

Primase DnaG is an essential bacterial enzyme that synthesizes short ribonucleotide primers required for chromosomal DNA replication. Inhibitors of DnaG can serve as leads for development of new antib...

9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, hydrochloride (1:2)

2,7-Bis-deae-fluorenone

2,7-Bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride

2,7-Bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride

bis-deae-fluorenonehydrochloride

TILORONE HYDROCHLORIDE

TILORONE 2HCL

2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

MFCD00134071

9H-Fluoren-9-one, 2,7-bis[2- (diethylamino)ethoxy]-, dihydrochloride

Tilorone DiHCl

Deae-f

2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one dihydrochloride

UNII-BJ507J4LKY

Tilorone (dihydrochloride)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tilorone dihydrochloride
Price: ￥2788.0/500mg ￥668.0/100mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tilorone dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Tilorone dihydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tilorone dihydrochloride cas 27591-69-1
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Tilorone dihydrochloride

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