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27591-69-1

27591-69-1 structure
27591-69-1 structure
  • Name: Tilorone dihydrochloride
  • Chemical Name: Tilorone dihydrochloride
  • CAS Number: 27591-69-1
  • Molecular Formula: C25H36Cl2N2O3
  • Molecular Weight: 483.471
  • Catalog: API Synthetic anti-infective drugs Antiviral drugs
  • Create Date: 2018-02-12 08:00:00
  • Modify Date: 2025-08-25 17:40:09
  • Tilorone dihydrochloride is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer, used as an antiviral drug.
Name Tilorone dihydrochloride
Synonyms 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, hydrochloride (1:2)
2,7-Bis-deae-fluorenone
2,7-Bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride
bis-deae-fluorenonehydrochloride
TILORONE HYDROCHLORIDE
TILORONE 2HCL
2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride
MFCD00134071
9H-Fluoren-9-one, 2,7-bis[2- (diethylamino)ethoxy]-, dihydrochloride
Tilorone DiHCl
Deae-f
2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one dihydrochloride
UNII-BJ507J4LKY
Tilorone (dihydrochloride)
Description Tilorone dihydrochloride is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer, used as an antiviral drug.
Related Catalog
Density 1.102g/cm3
Boiling Point 552.3ºC at 760 mmHg
Melting Point 230-233 °C(lit.)
Molecular Formula C25H36Cl2N2O3
Molecular Weight 483.471
Flash Point 287.8ºC
Exact Mass 482.210297
PSA 42.01000
LogP 5.94320
Vapour Pressure 3.05E-12mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LL9000000
CHEMICAL NAME :
Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride
CAS REGISTRY NUMBER :
27591-69-1
LAST UPDATED :
199606
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C25-H34-N2-O3.2Cl-H
MOLECULAR WEIGHT :
483.53
WISWESSER LINE NOTATION :
L B656 HVJ EO2N2&2 LO2N2&2 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
852 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
150 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
400 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
100 umol/L
REFERENCE :
FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 28,5,1972 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H319-H335-H351
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R20/21/22;R36/37/38;R40
Safety Phrases S7-S22-S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LL9000000
HS Code 2922509090
HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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