Synthetic Communications

New Synthetic Pathways to Tilorone Hydrochloride

SM Burke, MM Joullie

Index: Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

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Citation Number: 12

Abstract

Abstract Tilorone hydrochloride (1), the dihydrochloride of bis-2, 7-[(diethylamino) ethoxy] fluoren-9-one, is an orally active, interferon stimulating, antiviral agent in mice. 1, 2 Extensive studies have also shown the effectiveness of this compound as an antitumor and antiinflammatory agent. 3, 4 Tilorone hydrochloride is currently being investigated as an adjuvant in the early treatment of cancer. 5

[N-quaternary derivatives of tilorone]

[Schulze; Letsch; Gutsche; et al. Pharmazie, 1984 , vol. 39, # 5 p. 320 - 322]

Chronobiotic activity of N-[2-(2, 7-dimethoxyfluoren-9-yl) e...

[Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611]

3 H 2-Amyxin Synthesis and Isolation from Biological Substra...

[Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450]