AM-6494

Modify Date: 2024-01-09 17:09:16

AM-6494 structure	Common Name	AM-6494
	CAS Number	1874232-80-0	Molecular Weight	473.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₁F₂N₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AM-6494

AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].

Name	AM-6494

Description	AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Target	IC50: (BACE1), 18.6 nM (BACE2)[1]
References	[1]. Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18.

Molecular Formula	C₂₂H₂₁F₂N₅O₃S
Molecular Weight	473.50