AM-6494

Names

[ CAS No. ]:
1874232-80-0

[ Name ]:
AM-6494

Biological Activity

[Description]:

AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

[Target]

IC50: (BACE1), 18.6 nM (BACE2)[1]


[References]

[1]. Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H21F2N5O3S

[ Molecular Weight ]:
473.50

Related Compounds