1874232-80-0

1874232-80-0 structure

1874232-80-0 structure

Name: AM-6494
Chemical Name: AM-6494
CAS Number: 1874232-80-0
Molecular Formula: C₂₂H₂₁F₂N₅O₃S
Molecular Weight: 473.50
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2019-12-07 20:28:54
Modify Date: 2024-01-09 17:09:16
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].

Name	AM-6494

Description	AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Target	IC50: (BACE1), 18.6 nM (BACE2)[1]
References	[1]. Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18.

Molecular Formula	C₂₂H₂₁F₂N₅O₃S
Molecular Weight	473.50