TC AC 28

Modify Date: 2024-01-24 15:32:12

TC AC 28 Structure
TC AC 28 structure
Common Name TC AC 28
CAS Number 1809296-92-1 Molecular Weight 415.44
Density 1.4±0.1 g/cm3 Boiling Point 662.7±65.0 °C at 760 mmHg
Molecular Formula C23H21N5O3 Melting Point N/A
MSDS N/A Flash Point 354.6±34.3 °C

 Use of TC AC 28


TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2(2), Brd2(1), respectively[1].

 Names

Name TC AC 28
Synonym More Synonyms

 TC AC 28 Biological Activity

Description TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2(2), Brd2(1), respectively[1].
Related Catalog
Target

BRD2(1):40 nM (Kd)

BRD2(2):800 nM (EC50)

References

[1]. Khan R, et al. Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand. ACS Omega. 2017 Aug 8;2(8):4328-4332.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 662.7±65.0 °C at 760 mmHg
Molecular Formula C23H21N5O3
Molecular Weight 415.44
Flash Point 354.6±34.3 °C
Exact Mass 415.164429
LogP 2.08
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.701

 Synonyms

Methyl [6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate
6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid, 6-(1H-indol-4-yl)-8-methoxy-1-methyl-, methyl ester