TC-A 2317 hydrochloride
Modify Date: 2024-01-07 11:50:55
TC-A 2317 hydrochloride structure
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Common Name | TC-A 2317 hydrochloride | ||
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| CAS Number | 1245907-03-2 | Molecular Weight | 392.92600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H29ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-A 2317 hydrochlorideTC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1]. |
| Name | 2-[(6-Hydroxy-6-methyl-2-heptanyl)amino]-4-methyl-6-[(5-methyl-1H -pyrazol-3-yl)amino]nicotinonitrile hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1]. |
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| Related Catalog | |
| Target |
Aurora A:1.2 nM (Ki) Aurora B:101 nM (Ki) |
| In Vitro | TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM[1]. |
| In Vivo | TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight[1]. TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats[1]. Animal Model: HCT-116 Xenograft mice mode[1] Dosage: P.o.; daily for 14 days Administration: 30 mg/kg Result: Growth of tumor was inhibited by 59% after 14 days. |
| References |
| Molecular Formula | C19H29ClN6O |
|---|---|
| Molecular Weight | 392.92600 |
| Exact Mass | 392.20900 |
| PSA | 112.88000 |
| LogP | 4.07528 |
| TC-A 2317 hydrochloride |