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TC AC 28

Names

[ CAS No. ]:
1809296-92-1

[ Name ]:
TC AC 28

[Synonym ]:
Methyl [6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate
6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid, 6-(1H-indol-4-yl)-8-methoxy-1-methyl-, methyl ester

Biological Activity

[Description]:

TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2(2), Brd2(1), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD2(1):40 nM (Kd)

BRD2(2):800 nM (EC50)


[References]

[1]. Khan R, et al. Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand. ACS Omega. 2017 Aug 8;2(8):4328-4332.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
662.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H21N5O3

[ Molecular Weight ]:
415.44

[ Flash Point ]:
354.6±34.3 °C

[ Exact Mass ]:
415.164429

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.701

Related Compounds