TC KHNS 11

Names

[ Name ]:
TC KHNS 11

[Synonym ]:
MFCD31689242
3-Pyridinecarbonitrile, 5-[4-[3-[(4-acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-
5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-Carbonitrile
5-(4-{3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl}-6-quinazolinyl)-2-methoxynicotinonitrile

Biological Activity

[Description]:

PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

9 nM, 0.262 μM, 1.65 μM, 4.63 μM (PI3Kδ, PI3Kα, PI3Kβ, PI3Kγ)[1]

[References]

[1]. Hoegenauer K, et al. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2016 Jun 2;7(8):762-7.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
760.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₂₄N₆O₃

[ Molecular Weight ]:
492.53

[ Flash Point ]:
413.7±32.9 °C

[ Exact Mass ]:
492.190979

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.700

Related Compounds

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