Fosthiazate

Modify Date: 2024-01-02 19:12:54

Fosthiazate Structure
Fosthiazate structure
Common Name Fosthiazate
CAS Number 98886-44-3 Molecular Weight 283.348
Density 1.3±0.1 g/cm3 Boiling Point 371.3±25.0 °C at 760 mmHg
Molecular Formula C9H18NO3PS2 Melting Point N/A
MSDS Chinese USA Flash Point 178.3±23.2 °C
Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger

 Use of Fosthiazate


Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase[1].

 Names

Name fosthiazate
Synonym More Synonyms

 Fosthiazate Biological Activity

Description Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase[1].
Related Catalog
References

[1]. Lianshan Liet al. Chiral organophosphorous pesticide fosthiazate: absolute configuration, stereoselective bioactivity, toxicity, and degradation in vegetables. J Agric Food Chem. 2020 Jul 22;68(29):7609-7616.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 371.3±25.0 °C at 760 mmHg
Molecular Formula C9H18NO3PS2
Molecular Weight 283.348
Flash Point 178.3±23.2 °C
Exact Mass 283.046570
PSA 107.02000
LogP 0.94
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.541
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TB1707000
CHEMICAL NAME :
Phosphonothioic acid, (2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
CAS REGISTRY NUMBER :
98886-44-3
LAST UPDATED :
199506
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H18-N-O3-P-S2
MOLECULAR WEIGHT :
283.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
558 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
861 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994

 Safety Information

Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger
Hazard Statements H301 + H311 + H331-H317-H318-H410
Supplemental HS Toxic by eye contact.
Precautionary Statements Missing Phrase - N15.00950417-P280-P302 + P352 + P312-P304 + P340 + P312-P305 + P351 + P338 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases R21;R23/25;R39;R41;R43;R50/53
Safety Phrases S53-S25-S26-S39-S45-S60-S61
RIDADR UN 2810
RTECS TB1707000
Packaging Group III
Hazard Class 6.1(b)

 Synonyms

O-Ethyl S-(1-methylpropyl) (2-oxo-3-thiazolidinyl)phosphonothioate
O-ethyl S-(1-methylpropyl) P-(2-oxo-3-thiazolidinyl)phosphonothioate
Fosthiazate
Phosphonothioic acid, (2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
S-sec-Butyl O-ethyl 2-oxo-3-thiazolidinylphosphonothioate
Fosthiazate [ISO:BSI]
IKI 1145
O-Ethyl S-(1-methylpropyl) (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
MFCD00274595
T5NVSTJ APO2&S1Y2&1
(3RS)-3-[(RS)-sec-butylthio(ethoxy)phosphinoyl]-1,3-thiazolidin-2-one
(RS)-[S-(RS)-sec-butyl O-ethyl 2-oxo-1,3-thiazolidin-3-ylphosphonothioate]
3-[butan-2-ylsulfanyl(ethoxy)phosphoryl]-1,3-thiazolidin-2-one
O-Ethyl S-(butan-2-yl) (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
S-butan-2-yl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate
S-sec-Butyl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
Phosphonothioic acid, P-(2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
Nemathorin
S-sec-Butyl O-ethyl (2-oxo-1,3-thiazolidine-3-yl)phosphonothioate
(Ξ)-[S-(2Ξ)-butan-2-yl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate]
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