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Fosthiazate

Names

[ CAS No. ]:
98886-44-3

[ Name ]:
Fosthiazate

[Synonym ]:
O-Ethyl S-(1-methylpropyl) (2-oxo-3-thiazolidinyl)phosphonothioate
O-ethyl S-(1-methylpropyl) P-(2-oxo-3-thiazolidinyl)phosphonothioate
Fosthiazate
Phosphonothioic acid, (2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
S-sec-Butyl O-ethyl 2-oxo-3-thiazolidinylphosphonothioate
Fosthiazate [ISO:BSI]
IKI 1145
O-Ethyl S-(1-methylpropyl) (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
MFCD00274595
T5NVSTJ APO2&S1Y2&1
(3RS)-3-[(RS)-sec-butylthio(ethoxy)phosphinoyl]-1,3-thiazolidin-2-one
(RS)-[S-(RS)-sec-butyl O-ethyl 2-oxo-1,3-thiazolidin-3-ylphosphonothioate]
3-[butan-2-ylsulfanyl(ethoxy)phosphoryl]-1,3-thiazolidin-2-one
O-Ethyl S-(butan-2-yl) (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
S-butan-2-yl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate
S-sec-Butyl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate
Phosphonothioic acid, P-(2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
Nemathorin
S-sec-Butyl O-ethyl (2-oxo-1,3-thiazolidine-3-yl)phosphonothioate
(Ξ)-[S-(2Ξ)-butan-2-yl O-ethyl (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate]

Biological Activity

[Description]:

Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Lianshan Liet al. Chiral organophosphorous pesticide fosthiazate: absolute configuration, stereoselective bioactivity, toxicity, and degradation in vegetables. J Agric Food Chem. 2020 Jul 22;68(29):7609-7616.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
371.3±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H18NO3PS2

[ Molecular Weight ]:
283.348

[ Flash Point ]:
178.3±23.2 °C

[ Exact Mass ]:
283.046570

[ PSA ]:
107.02000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TB1707000
CHEMICAL NAME :
Phosphonothioic acid, (2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester
CAS REGISTRY NUMBER :
98886-44-3
LAST UPDATED :
199506
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H18-N-O3-P-S2
MOLECULAR WEIGHT :
283.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
558 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
861 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
91 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (65),13,1994

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H317-H318-H410

[ Supplemental HS ]:
Toxic by eye contact.

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P280-P302 + P352 + P312-P304 + P340 + P312-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R21;R23/25;R39;R41;R43;R50/53

[ Safety Phrases ]:
S53-S25-S26-S39-S45-S60-S61

[ RIDADR ]:
UN 2810

[ RTECS ]:
TB1707000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)