Sephin 1
Modify Date: 2025-08-25 08:54:14
Sephin 1 structure
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Common Name | Sephin 1 | ||
|---|---|---|---|---|
| CAS Number | 951441-04-6 | Molecular Weight | 196.637 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 374.2±44.0 °C at 760 mmHg | |
| Molecular Formula | C8H9ClN4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 180.1±28.4 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Sephin 1Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice. |
| Name | Ifb-088 |
|---|---|
| Synonym | More Synonyms |
| Description | Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice. |
|---|---|
| References | References 1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42. View Related Products by Target Protein Phosphatase/PTP |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 374.2±44.0 °C at 760 mmHg |
| Molecular Formula | C8H9ClN4 |
| Molecular Weight | 196.637 |
| Flash Point | 180.1±28.4 °C |
| Exact Mass | 196.051575 |
| LogP | 1.79 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.626 |
| InChIKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |
| SMILES | NC(N)=NN=Cc1ccccc1Cl |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| Sephin 1 |
| 9M998304JB |
| Ifb-088 |
| N''-[(E)-(2-Chlorophenyl)methylene]carbonohydrazonic diamide |
| (E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide |
| Sephin1 |
| Carbonohydrazonic diamide, N''-[(1E)-(2-chlorophenyl)methylene]- |
| MFCD00790608 |