951441-04-6

951441-04-6 structure

Name: Sephin 1
Chemical Name: Ifb-088
CAS Number: 951441-04-6
Molecular Formula: C₈H₉ClN₄
Molecular Weight: 196.637
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2020-01-11 17:42:56
Modify Date: 2025-08-25 08:54:14
Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice.

Name	Ifb-088
Synonyms	Sephin 1 9M998304JB Ifb-088 N''-[(E)-(2-Chlorophenyl)methylene]carbonohydrazonic diamide (E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide Sephin1 Carbonohydrazonic diamide, N''-[(1E)-(2-chlorophenyl)methylene]- MFCD00790608

Description	Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice.
References	References 1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42. View Related Products by Target Protein Phosphatase/PTP