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Sephin 1

Names

[ CAS No. ]:
951441-04-6

[ Name ]:
Sephin 1

[Synonym ]:
Sephin 1
9M998304JB
Ifb-088
N''-[(E)-(2-Chlorophenyl)methylene]carbonohydrazonic diamide
(E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide
Sephin1
Carbonohydrazonic diamide, N''-[(1E)-(2-chlorophenyl)methylene]-
MFCD00790608

Biological Activity

[Description]:

Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice.

[References]

References 1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
374.2±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H9ClN4

[ Molecular Weight ]:
196.637

[ Flash Point ]:
180.1±28.4 °C

[ Exact Mass ]:
196.051575

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.626

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds