ALX-1393

Modify Date: 2024-01-10 16:42:23

ALX-1393 structure	Common Name	ALX-1393
	CAS Number	949164-09-4	Molecular Weight	395.42300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₂FNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALX-1393

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

Name	O-[(2-benzyloxyphenyl)(3-fluorophenyl)methyl]-L-serine

Description	ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GlyT
Target	GlyT2[1]
In Vivo	ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].
References	[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21. [2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52.

Molecular Formula	C₂₃H₂₂FNO₄
Molecular Weight	395.42300
Exact Mass	395.15300
PSA	81.78000
LogP	4.62290

DC Chemicals Limited
China
Product Name: ALX-1393
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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