ALX-1393

Names

[ Name ]:
ALX-1393

Biological Activity

[Description]:

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GlyT

[Target]

GlyT2[1]

[In Vivo]

ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].

[References]

[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21.

[2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂FNO₄

[ Molecular Weight ]:
395.42300

[ Exact Mass ]:
395.15300

[ PSA ]:
81.78000

[ LogP ]:
4.62290

Related Compounds

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