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NPS ALX Compound 4a

Names

[ CAS No. ]:
299433-10-6

[ Name ]:
NPS ALX Compound 4a

[Synonym ]:
Cyanopindolol hemifumarate

Biological Activity

[Description]:

NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

IC50: 7.2 nM (5-HT6 receptor) Ki: 0.2 nM (5-HT6 receptor)


[References]

[1]. Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1719-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H25N3O2S

[ Molecular Weight ]:
431.55

[ Exact Mass ]:
503.12000

[ PSA ]:
53.93000

[ LogP ]:
7.00360

Related Compounds