A-803467
A-803467 structure
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Common Name | A-803467 | ||
|---|---|---|---|---|
| CAS Number | 944261-79-4 | Molecular Weight | 357.788 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 450.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H16ClNO4 | Melting Point | 128-130?C | |
| MSDS | Chinese USA | Flash Point | 226.3±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of A-803467A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. |
| Name | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 450.6±45.0 °C at 760 mmHg |
| Melting Point | 128-130?C |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.788 |
| Flash Point | 226.3±28.7 °C |
| Exact Mass | 357.076782 |
| PSA | 60.70000 |
| LogP | 4.93 |
| Appearance of Characters | white to tan |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.611 |
| InChIKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
| SMILES | COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: >10mg/mL |
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~%
A-803467 CAS#:944261-79-4 |
| Literature: Journal of Medicinal Chemistry, , vol. 51, # 3 p. 407 - 416 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2932190090 |
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| Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc. Natl. Acad. Sci. U. S. A. 104 , 8520-5, (2007) Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel... |
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Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.
Mol. Interv. 7 , 192-5, (2007) Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics... |
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Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.
Circ. Res. 111 , 333-43, (2012) The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR interval and QRS duration, strongly suggesting an as-yet u... |
| 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
| 2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)- |
| cc-433 |
| A-803467 |