5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺结构式
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常用名 | 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺 | 英文名 | A-803467 |
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CAS号 | 944261-79-4 | 分子量 | 357.788 | |
密度 | 1.3±0.1 g/cm3 | 沸点 | 450.6±45.0 °C at 760 mmHg | |
分子式 | C19H16ClNO4 | 熔点 | 128-130?C | |
MSDS | 中文版 美版 | 闪点 | 226.3±28.7 °C | |
符号 |
GHS07 |
信号词 | Warning |
用途A 803467是Nav1.8钠离子通道阻断剂,IC50为8 nM,比对Nav1.2,1.3,1.5和1.7的抑制性高100倍。 |
中文名 | 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺 |
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英文名 | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide |
英文别名 | 更多 |
描述 | A 803467是Nav1.8钠离子通道阻断剂,IC50为8 nM,比对Nav1.2,1.3,1.5和1.7的抑制性高100倍。 |
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相关类别 | |
参考文献 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 450.6±45.0 °C at 760 mmHg |
熔点 | 128-130?C |
分子式 | C19H16ClNO4 |
分子量 | 357.788 |
闪点 | 226.3±28.7 °C |
精确质量 | 357.076782 |
PSA | 60.70000 |
LogP | 4.93 |
外观性状 | white to tan |
蒸汽压 | 0.0±1.1 mmHg at 25°C |
折射率 | 1.611 |
储存条件 | Store at +4°C |
水溶解性 | DMSO: >10mg/mL |
~% 5-(4-氯苯基)-N-(3,... 944261-79-4 |
文献:Journal of Medicinal Chemistry, , vol. 51, # 3 p. 407 - 416 |
上游产品 2 | |
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下游产品 0 |
海关编码 | 2932190090 |
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中文概述 | 2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc. Natl. Acad. Sci. U. S. A. 104 , 8520-5, (2007) Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel... |
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Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.
Mol. Interv. 7 , 192-5, (2007) Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics... |
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Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.
Circ. Res. 111 , 333-43, (2012) The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR interval and QRS duration, strongly suggesting an as-yet u... |
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)- |
cc-433 |
A-803467 |