5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺

更新时间:2024-01-09 23:02:11

5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺结构式
5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺结构式
品牌特惠专场
常用名 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺 英文名 A-803467
CAS号 944261-79-4 分子量 357.788
密度 1.3±0.1 g/cm3 沸点 450.6±45.0 °C at 760 mmHg
分子式 C19H16ClNO4 熔点 128-130?C
MSDS 中文版 美版 闪点 226.3±28.7 °C
符号 GHS07
GHS07
信号词 Warning

 用途


A 803467是Nav1.8钠离子通道阻断剂,IC50为8 nM,比对Nav1.2,1.3,1.5和1.7的抑制性高100倍。

 名称

中文名 5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺
英文名 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
英文别名 更多

 物理化学性质

密度 1.3±0.1 g/cm3
沸点 450.6±45.0 °C at 760 mmHg
熔点 128-130?C
分子式 C19H16ClNO4
分子量 357.788
闪点 226.3±28.7 °C
精确质量 357.076782
PSA 60.70000
LogP 4.93
外观性状 white to tan
蒸汽压 0.0±1.1 mmHg at 25°C
折射率 1.611
储存条件 Store at +4°C
水溶解性 DMSO: >10mg/mL

 安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
危害码 (欧洲) Xn
风险声明 (欧洲) R22
危险品运输编码 NONH for all modes of transport
海关编码 2932190090

 上下游产品

上游产品  2

下游产品  0

 海关

海关编码 2932190090
中文概述 2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 文献4

更多文献
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

Proc. Natl. Acad. Sci. U. S. A. 104 , 8520-5, (2007)

Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel...

Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.

Mol. Interv. 7 , 192-5, (2007)

Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics...

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Circ. Res. 111 , 333-43, (2012)

The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR interval and QRS duration, strongly suggesting an as-yet u...

 英文别名

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide
2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-
cc-433
A-803467
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