BAZ1A-IN-1
Modify Date: 2025-08-27 19:07:09
BAZ1A-IN-1 structure
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Common Name | BAZ1A-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 941521-45-5 | Molecular Weight | 340.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAZ1A-IN-1BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. |
| Name | BAZ1A-IN-1 |
|---|
| Description | BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. |
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| Related Catalog | |
| Target |
BAZ1A[1] |
| In Vitro | BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1]. Cell Viability Assay[1] Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells Concentration: 0.015-100 μM Incubation Time: 96 hours Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A. |
| References |
| Molecular Formula | C16H12N4O3S |
|---|---|
| Molecular Weight | 340.36 |
| InChIKey | UJRJAZDAWUSWRK-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cccc([N+](=O)[O-])c1)Nc1nc(-c2ccccc2)cs1 |