941521-45-5

941521-45-5 structure

Name: BAZ1A-IN-1
Chemical Name: BAZ1A-IN-1
CAS Number: 941521-45-5
Molecular Formula: C₁₆H₁₂N₄O₃S
Molecular Weight: 340.36
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-03-04 07:11:19
Modify Date: 2024-01-08 10:34:38
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

Name	BAZ1A-IN-1

Description	BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BAZ1A[1]
In Vitro	BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1]. Cell Viability Assay[1] Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells Concentration: 0.015-100 μM Incubation Time: 96 hours Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.
References	[1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

Molecular Formula	C₁₆H₁₂N₄O₃S
Molecular Weight	340.36