BMS 795311
Modify Date: 2024-01-08 17:39:14
BMS 795311 structure
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Common Name | BMS 795311 | ||
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| CAS Number | 939390-99-5 | Molecular Weight | 671.525 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 620.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C33H23F10NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 328.8±31.5 °C | |
Use of BMS 795311BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM; inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters. |
| Name | N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide |
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| Synonym | More Synonyms |
| Description | BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM; inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters. |
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| References | References 1. Qiao JX, et al. J Med Chem. 2015 Nov 25;58(22):9010-26. View Related Products by Target CETP |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 620.1±55.0 °C at 760 mmHg |
| Molecular Formula | C33H23F10NO3 |
| Molecular Weight | 671.525 |
| Flash Point | 328.8±31.5 °C |
| Exact Mass | 671.151855 |
| LogP | 10.38 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.538 |
| N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide |
| Benzamide, N-[(1R)-1-[3-(cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)- |