BMS 795311

Names

[ Name ]:
BMS 795311

[Synonym ]:
N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide
Benzamide, N-[(1R)-1-[3-(cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)-

Biological Activity

[Description]:

BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM; inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters.

[References]

References 1. Qiao JX, et al. J Med Chem. 2015 Nov 25;58(22):9010-26. View Related Products by Target CETP

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
620.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₃H₂₃F₁₀NO₃

[ Molecular Weight ]:
671.525

[ Flash Point ]:
328.8±31.5 °C

[ Exact Mass ]:
671.151855

[ LogP ]:
10.38

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.538

Related Compounds

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