6-Methylcoumarin

Modify Date: 2024-01-02 11:05:54

6-Methylcoumarin structure	Common Name	6-Methylcoumarin
	CAS Number	92-48-8	Molecular Weight	160.169
	Density	1.2±0.1 g/cm3	Boiling Point	304.6±21.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₂	Melting Point	73-76 °C(lit.)
	MSDS	Chinese USA	Flash Point	124.3±19.5 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of 6-Methylcoumarin

6-Methylcoumarin is a synthetic fragrance widely used in cosmetics.

Name	6-methylcoumarin
Synonym	More Synonyms

Description	6-Methylcoumarin is a synthetic fragrance widely used in cosmetics.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Phenylpropanoids Research Areas >> Others
In Vitro	6-Methylcoumarin is reported to be almost nonphototoxic in epidermal tissue and cell culture phototoxicity test models. HaCaT cells are treated with 6-Methylcoumarin (1-105 nM) and/or UVA (5 J cm-2), and γ-H2AX is detected by immunofluorescence staining and western blotting 4hours after the treatments. 6-Methylcoumarin clearly produces γ-H2AX-positive cells under UVA irradiation from a concentration of 100 nM[1].
References	[1]. Toyooka T, et al. Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. J Invest Dermatol. 2011 Jun;131(6):1313-21.

Density	1.2±0.1 g/cm3
Boiling Point	304.6±21.0 °C at 760 mmHg
Melting Point	73-76 °C(lit.)
Molecular Formula	C₁₀H₈O₂
Molecular Weight	160.169
Flash Point	124.3±19.5 °C
Exact Mass	160.052429
PSA	30.21000
LogP	1.85
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.583

6-Methylcoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN7792000

CHEMICAL NAME :: Coumarin, 6-methyl-

CAS REGISTRY NUMBER :: 92-48-8

BEILSTEIN REFERENCE NO. :: 0004222

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

WISWESSER LINE NOTATION :: T66 BOVJ H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 253 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2500 umol/L

REFERENCE :: HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 69,35,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5104 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 24 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R42/43
Safety Phrases	S22-S36/37-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GN7792000
HS Code	2932209090

Precursor 9
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CAS#:110-16-7 Maleic acid
DownStream 10
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CAS#:18385-83-6 6-methyl-2H-chromene CAS#:827007-19-2 (4R)-6-Methyl-4...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

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A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans.

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6-Methylcoumarin

T66 BOVJ H1

EINECS 202-158-8

MFCD00006875

6 METHYL COUMARIN

BioBioPha
China
Product Name: 6-Methylcoumarin
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-Methylcoumarin
Price: ￥348.0/100g ￥118.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-Methylcoumarin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 92-48-8 6-Methylcoumarin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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6-Methylcoumarin

Use of 6-Methylcoumarin

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