Ro 25-6981 hydrochloride
Modify Date: 2025-08-25 19:10:41
Ro 25-6981 hydrochloride structure
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Common Name | Ro 25-6981 hydrochloride | ||
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| CAS Number | 919289-58-0 | Molecular Weight | 375.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H30ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ro 25-6981 hydrochlorideRo 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3]. |
| Name | 4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]ph enol hydrochloride (1:1) |
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| Description | Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3]. |
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| Related Catalog | |
| In Vitro | Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3]. |
| In Vivo | Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3]. Animal Model: 6-OHDA-lesioned rats[1] Dosage: 0.39-12.5 mg/kg Administration: I.p. Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound. Animal Model: Male albino rats of Wistar strain[2] Dosage: 1, 3 mg/kg Administration: I.p. Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development. |
| References |
| Molecular Formula | C22H30ClNO2 |
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| Molecular Weight | 375.93 |
| Exact Mass | 375.19700 |
| PSA | 43.70000 |
| LogP | 4.75630 |
| InChIKey | MKTZWXWTQQOMSH-OTCZLQCGSA-N |
| SMILES | CC(CN1CCC(Cc2ccccc2)CC1)C(O)c1ccc(O)cc1.Cl |
| Hazard Codes | Xi |
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