Guaiacol

Modify Date: 2024-01-02 16:02:01

Guaiacol structure	Common Name	Guaiacol
	CAS Number	90-05-1	Molecular Weight	124.14
	Density	1.2±0.1 g/cm3	Boiling Point	207.5±29.0 °C at 760 mmHg
	Molecular Formula	C₇H₈O₂	Melting Point	26-29 °C(lit.)
	MSDS	Chinese USA	Flash Point	79.3±24.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Guaiacol

Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].

Name	guaiacol
Synonym	More Synonyms

Description	Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].
Related Catalog	Natural Products >> Phenols Research Areas >> Inflammation/Immunology
Target	COX-2 NF-κB
In Vitro	Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM)[1].
References	[1]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7.

Density	1.2±0.1 g/cm3
Boiling Point	207.5±29.0 °C at 760 mmHg
Melting Point	26-29 °C(lit.)
Molecular Formula	C₇H₈O₂
Molecular Weight	124.14
Flash Point	79.3±24.3 °C
PSA	29.46000
LogP	2.11
Vapour density	4.27 (vs air)
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.538
Storage condition	Refrigerator
Stability	Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	17 g/L (15 ºC)
Freezing Point	28℃

Guaiacol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL7525000

CHEMICAL NAME :: Phenol, o-methoxy-

CAS REGISTRY NUMBER :: 90-05-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

WISWESSER LINE NOTATION :: QR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 621 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7570 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21215 mg/kg/40D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 169,129,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2844 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 1596 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2844 No. of Facilities: 34 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 2101 (estimated) No. of Female Employees: 297 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319
Precautionary Statements	P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/38
Safety Phrases	S26
RIDADR	2810
WGK Germany	1
RTECS	SL7525000
Packaging Group	II
Hazard Class	6.1(b)
HS Code	2909500000

Precursor 10
CAS#:5720-06-9 2-Methoxyphenyl... CAS#:578-57-4 bromoanisole CAS#:529-28-2 iodoanisole CAS#:766-51-8 2-Chloroanisole
CAS#:10535-17-8 1-(3,4-Dimethox... CAS#:121-33-5 Vanillin CAS#:10548-82-0 1,2-dimethoxy-4... CAS#:100-66-3 Anisole
CAS#:91-16-7 1,2-Dimethoxybenzene CAS#:118-93-4 Ortho-Hydroxyac...
DownStream 10
CAS#:10493-37-5 3-(2-Methoxyphe... CAS#:110030-28-9 4-butan-2-yl-2-... CAS#:203861-62-5 4-Iodoguiacol CAS#:111726-46-6 2-Iodo-6-methox...
CAS#:105602-16-2 1-[2-(2-METHOXY... CAS#:10548-82-0 1,2-dimethoxy-4... CAS#:107952-04-5 3-[(2-methoxyph... CAS#:34123-66-5 3-Isopropoxy-4-...
CAS#:3743-23-5 5-chloro-2-meth... CAS#:57695-98-4 3-Methoxy-4-pro...

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

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ChemSusChem 8 , 4081-5, (2015)

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5-fluoro-2,3-dihydro-1h-isoindole

2-Methoxyphenol

methoxyphenol

2,3-dihydro-6-fluoro-1H-indole

o-Methoxyphenol

Guaiacol

MFCD00002185

Indoline, 6-fluoro-

2-Hydroxyanisole

2-Methoxy-phenol

o-Methylcatechol

2,3-dihydro-6-fluoroindole

Catechol, Methyl

o-methoxy-Phenol

6-Fluor-indolin

6-Fluoroindoline

ORTHO-METHOXYPHENOL

6-fluoro-2,3-dihydro-indole

Phenol, 2-methoxy-

o-methoxy catechol

O-Methyl catechol

1H-Indole, 6-fluoro-2,3-dihydro-

Indoline,6-fluoro

Methylcatechol

EINECS 201-964-7

Catechol monomethyl ether

o-Hydroxyanisole

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Guaiacol
Price: ￥48.0/100g ￥158.0/20mg ￥118.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Guaiacol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Guaiacol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Guaiacol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Guaiacol

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