Metorphamide

Modify Date: 2024-01-03 18:52:45

Use of Metorphamide

Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM.

Name	adrenorphin
Synonym	More Synonyms

Description	Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Cancer Peptides
Target	Ki: 12 nM (μ-opioid receptor)[1]
In Vitro	Adrenorphin (Metorphamide) is a opioid octapeptide from bovine brain, acts as a potent agonist of μ-opioid receptor, with Ki of 12 nM. The binding ratios of Ki for μ-opioid receptor/Ki for δ-opioid receptor of 0.04 and of Ki for μ-opioid receptor/Ki for κ-opioid receptor of 0.46[1]. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with an IC50 of 1.1 μM[2].
References	[1]. Weber E, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6. [2]. Yanase T, et al. Studies on adrenorphin in pheochromocytoma. J Clin Endocrinol Metab. 1987 Apr;64(4):692-7.

WGK Germany	3

H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2

METORPHINAMIDE

METORPHAMIDE

PROENKEPHALIN (206-213) (BOVINE)

adrenorphin amide

TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2

METORPHIN

tyr-gly-gly-phe-met-arg-arg-val amide

Get all suppliers and price by the below link:

Price: ￥770/1 mg

Reference only. check more Metorphamide price