LtaS-IN-1
Modify Date: 2025-08-25 20:17:37
LtaS-IN-1 structure
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Common Name | LtaS-IN-1 | ||
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| CAS Number | 877950-01-1 | Molecular Weight | 427.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H17N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LtaS-IN-1LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1]. |
| Name | LtaS-IN-1 |
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| Description | LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1]. |
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| Related Catalog | |
| Target |
MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)[1] |
| In Vitro | LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group[1]. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL[1]. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively[1]. |
| References |
| Molecular Formula | C24H17N3O5 |
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| Molecular Weight | 427.41 |
| Hazard Codes | Xi |
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