877950-01-1

877950-01-1 structure

Name: LtaS-IN-1
Chemical Name: LtaS-IN-1
CAS Number: 877950-01-1
Molecular Formula: C₂₄H₁₇N₃O₅
Molecular Weight: 427.41
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-04-07 16:20:58
Modify Date: 2025-08-25 20:17:37
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].

Name	LtaS-IN-1

Description	LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)[1]
In Vitro	LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group[1]. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL[1]. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively[1].
References	[1]. Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents. 2017 Mar;49(3):355-363.

Molecular Formula	C₂₄H₁₇N₃O₅
Molecular Weight	427.41

Hazard Codes	Xi

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

877950-01-1	1964515-43-2
2573979-31-2	2123491-32-5
924296-18-4	877225-09-7
1889281-94-0	1207358-59-5
2730022-10-1	2648290-28-0
901019-05-4	901045-67-8
901024-29-1	373361-71-8
133059-47-9	898445-65-3
76469-43-7	898434-68-9
898434-78-1	898434-83-8