VU0238441
Modify Date: 2024-01-12 12:41:06
VU0238441 structure
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Common Name | VU0238441 | ||
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| CAS Number | 85511-68-8 | Molecular Weight | 339.69600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H9ClF3NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU0238441VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2]. |
| Name | 7-Chloro-1-[4-(trifluoromethyl)benzyl]-1H-indole-2,3-dione |
|---|---|
| Synonym | More Synonyms |
| Description | VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2]. |
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| Related Catalog | |
| Target |
EC50: 3.2 μM (M1), 2.8 μM (M2), 2.2 μM (M3), 2.1 μM (M5) and >10 μM (M4)[1] |
| In Vitro | VU0238441 is an analogue of VU0119498[2]. |
| References |
| Molecular Formula | C16H9ClF3NO2 |
|---|---|
| Molecular Weight | 339.69600 |
| Exact Mass | 339.02700 |
| PSA | 37.38000 |
| LogP | 4.15330 |
| Hazard Codes | Xn |
|---|
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~95%
VU0238441 CAS#:85511-68-8 |
| Literature: Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448 |
| Precursor 2 | |
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| DownStream 0 | |
| VU0238441 |