VU0238441

Modify Date: 2025-09-19 12:55:39

VU0238441 structure	Common Name	VU0238441
	CAS Number	85511-68-8	Molecular Weight	339.69600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₉ClF₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VU0238441

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

Name	7-Chloro-1-[4-(trifluoromethyl)benzyl]-1H-indole-2,3-dione
Synonym	More Synonyms

Description	VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	EC50: 3.2 μM (M1), 2.8 μM (M2), 2.2 μM (M3), 2.1 μM (M5) and >10 μM (M4)[1]
In Vitro	VU0238441 is an analogue of VU0119498[2].
References	[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.

Molecular Formula	C₁₆H₉ClF₃NO₂
Molecular Weight	339.69600
Exact Mass	339.02700
PSA	37.38000
LogP	4.15330

Hazard Codes	Xn

7-Chloroisatin

CAS#:7477-63-6

1-(Bromomethyl)...

CAS#:402-49-3

~95%

VU0238441

CAS#:85511-68-8

Literature: Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448

Precursor 2
CAS#:7477-63-6 7-Chloroisatin CAS#:402-49-3 1-(Bromomethyl)...
DownStream 0

VU0238441

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VU0238441
Price: Check
Purity: 97.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: VU0238441
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: VU0238441
Price: $500.0/250mg $250.0/100mg $1000.0/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥550/10 mM * 1 mL in DMSO

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VU0238441

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.