DC Chemicals Limited
China
Product Name: VU0238441
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

85511-68-8

85511-68-8 structure

Name: VU0238441
Chemical Name: 7-Chloro-1-[4-(trifluoromethyl)benzyl]-1H-indole-2,3-dione
CAS Number: 85511-68-8
Molecular Formula: C₁₆H₉ClF₃NO₂
Molecular Weight: 339.69600
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2016-12-23 20:14:33
Modify Date: 2024-01-12 12:41:06
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

Name	7-Chloro-1-[4-(trifluoromethyl)benzyl]-1H-indole-2,3-dione
Synonyms	VU0238441

Description	VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	EC50: 3.2 μM (M1), 2.8 μM (M2), 2.2 μM (M3), 2.1 μM (M5) and >10 μM (M4)[1]
In Vitro	VU0238441 is an analogue of VU0119498[2].
References	[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.

Molecular Formula	C₁₆H₉ClF₃NO₂
Molecular Weight	339.69600
Exact Mass	339.02700
PSA	37.38000
LogP	4.15330

Hazard Codes	Xn

7477-63-6

402-49-3

~95%

85511-68-8

Literature: Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448

Precursor 2
7477-63-6 402-49-3
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4