Cycloastragenol

Modify Date: 2025-08-23 08:58:44

Cycloastragenol structure	Common Name	Cycloastragenol
	CAS Number	84605-18-5	Molecular Weight	490.715
	Density	1.2±0.1 g/cm3	Boiling Point	617.2±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₅₀O₅	Melting Point	N/A
	MSDS	USA	Flash Point	327.1±31.5 °C

Use of Cycloastragenol

Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].

Name	cycloastragenol
Synonym	More Synonyms

Description	Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others
References	[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and Pharmacokinetics Volume 25, Issue 5, 2010, Pages 477-486 [2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04 [3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Terpenoids and Glycosides

Research Areas >> Others

References

[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and Pharmacokinetics Volume 25, Issue 5, 2010, Pages 477-486

[2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04

[3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.

Density	1.2±0.1 g/cm3
Boiling Point	617.2±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₀O₅
Molecular Weight	490.715
Flash Point	327.1±31.5 °C
Exact Mass	490.365814
PSA	90.15000
LogP	3.82
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.582
Storage condition	-20°C

HS Code	2942000000

Precursor 9
CAS#:83207-58-3 Astragaloside A CAS#:84676-89-1 Astragaloside II CAS#:86764-11-6 Astrasieversian... CAS#:84676-88-0 Isoastragaloside I
CAS#:84687-47-8 Acetytastragaloside CAS#:84680-75-1 Astragaloside I CAS#:84687-42-3 Astragaloside III CAS#:84687-44-5 astragaloside V
CAS#:84687-46-7 astragaloside VII
DownStream 0