Astragaloside A

Modify Date: 2024-01-03 00:40:12

Astragaloside A structure	Common Name	Astragaloside A
	CAS Number	83207-58-3	Molecular Weight	784.970
	Density	1.4±0.1 g/cm3	Boiling Point	895.7±65.0 °C at 760 mmHg
	Molecular Formula	C₄₁H₆₈O₁₄	Melting Point	284-286ºC
	MSDS	N/A	Flash Point	495.5±34.3 °C

Use of Astragaloside A

Astragaloside A is one of the major active constituents of Astragalus membranaceus in Traditional Chinese Medicine; has been widely used to treat ischemic diseases.IC50 value: Target: in vitro: AS-IV treatment promotes umbilical vein endothelial cells (HUVEC) proliferation, migration, and tube formation. AS-IV treatment also activates JAK2/STAT3 and ERK1/2 signaling pathways, and up-regulates endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production [1]. Administration of astragaloside IV (16, 32, and 64 μM) 1 h prior to lipopolysaccharide stimulation dose-dependently attenuated cardiac hypertrophy induced by lipopolysaccharide. Further studies demonstrated that astragaloside IV inhibited the increment of the resting intracellular free Ca2+, and its effect was similar to verapamil [2]. ASI could inhibit cells apoptosis induced by high glucose (25mmol/L) in dose-dependent and time-dependent manners. ASI also inhibited high glucose-induced expression of TGF-β1 and activation of p38 MAPK pathway at the protein level. Furthermore, ASI increased HGF production in human tubular epithelial cells [3].in vivo: the growth of tumor was suppressed by AS-IV treatment in vivo. AS-IV also could down-regulate regulatory T cells (Tregs) and up-regulate cytotoxic T lymphocytes (CTLs) in vivo and in vitro[4]. As an in vivo model, mice subjected to unilateral ureteral obstruction (UUO) were administered AS-IV (20 mg/kg) by intraperitoneal injection for 7 days. AS-IV significantly alleviated renal mass loss and reduced the expression of α-smooth muscle actin, fibronectin, and collagen IV both in vitro and in vivo [5].

Name	astragaloside IV
Synonym	More Synonyms

Description	Astragaloside A is one of the major active constituents of Astragalus membranaceus in Traditional Chinese Medicine; has been widely used to treat ischemic diseases.IC50 value: Target: in vitro: AS-IV treatment promotes umbilical vein endothelial cells (HUVEC) proliferation, migration, and tube formation. AS-IV treatment also activates JAK2/STAT3 and ERK1/2 signaling pathways, and up-regulates endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production [1]. Administration of astragaloside IV (16, 32, and 64 μM) 1 h prior to lipopolysaccharide stimulation dose-dependently attenuated cardiac hypertrophy induced by lipopolysaccharide. Further studies demonstrated that astragaloside IV inhibited the increment of the resting intracellular free Ca2+, and its effect was similar to verapamil [2]. ASI could inhibit cells apoptosis induced by high glucose (25mmol/L) in dose-dependent and time-dependent manners. ASI also inhibited high glucose-induced expression of TGF-β1 and activation of p38 MAPK pathway at the protein level. Furthermore, ASI increased HGF production in human tubular epithelial cells [3].in vivo: the growth of tumor was suppressed by AS-IV treatment in vivo. AS-IV also could down-regulate regulatory T cells (Tregs) and up-regulate cytotoxic T lymphocytes (CTLs) in vivo and in vitro[4]. As an in vivo model, mice subjected to unilateral ureteral obstruction (UUO) were administered AS-IV (20 mg/kg) by intraperitoneal injection for 7 days. AS-IV significantly alleviated renal mass loss and reduced the expression of α-smooth muscle actin, fibronectin, and collagen IV both in vitro and in vivo [5].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer
References	[1]. Wang SG, et al. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules. 2013 Oct 16;18(10):12809-19. [2]. Lu M, et al. Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+/CaN signaling pathway. Planta Med. 2014 Jan;80(1):63-9. [3]. Wang Q, et al. Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells. Ren Fail. 2014 Apr;36(3):400-6. [4]. Zhang A, et al. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. J Cancer Res Clin Oncol. 2014 Nov;140(11):1883-90. [5]. Xu W, et al. Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 2014 Sep;350(3):552-62.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Terpenoids and Glycosides

Research Areas >> Cancer

References

[1]. Wang SG, et al. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules. 2013 Oct 16;18(10):12809-19.

[2]. Lu M, et al. Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+/CaN signaling pathway. Planta Med. 2014 Jan;80(1):63-9.

[3]. Wang Q, et al. Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells. Ren Fail. 2014 Apr;36(3):400-6.

[4]. Zhang A, et al. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. J Cancer Res Clin Oncol. 2014 Nov;140(11):1883-90.

[5]. Xu W, et al. Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 2014 Sep;350(3):552-62.

Density	1.4±0.1 g/cm3
Boiling Point	895.7±65.0 °C at 760 mmHg
Melting Point	284-286ºC
Molecular Formula	C₄₁H₆₈O₁₄
Molecular Weight	784.970
Flash Point	495.5±34.3 °C
Exact Mass	784.460938
PSA	228.22000
LogP	1.96
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.621
Storage condition	2~8℃

Hazard Codes	Xi
HS Code	2932999099

astragaloside VII

CAS#:84687-46-7

Astragaloside A

CAS#:83207-58-3

Cycloastragenol...

CAS#:86764-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 716 - 722

Astragaloside VI

CAS#:84687-45-6

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 709 - 715

Astrasieversian...

CAS#:86764-11-6

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

Isoastragaloside I

CAS#:84676-88-0

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

Acetytastragaloside

CAS#:84687-47-8

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

Astragaloside II

CAS#:84676-89-1

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

Astragaloside I

CAS#:84680-75-1

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

trajanoside A

CAS#:223924-10-5

Astragaloside A

CAS#:83207-58-3

Literature: Chemistry of Natural Compounds, , vol. 40, # 1 p. 40 - 44

Precursor 7
CAS#:84687-46-7 astragaloside VII CAS#:84687-45-6 Astragaloside VI CAS#:86764-11-6 Astrasieversian... CAS#:84676-88-0 Isoastragaloside I
CAS#:84687-47-8 Acetytastragaloside CAS#:84676-89-1 Astragaloside II CAS#:84680-75-1 Astragaloside I
DownStream 2
CAS#:84605-18-5 Cycloastragenol CAS#:86764-12-7 Cycloastragenol...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Astragalus Polysaccharides

(3β,6α,9β,16β,20R,24S)-16,25-Dihydroxy-3-(β-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside

ASTRAGALOSIDE

ASTRAGALOSIDE IV(RG)

Astrasieversianin XIV

Astragaloside IV

Astragaloside A

β-D-Glucopyranoside, (3β,6α,9β,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

cyclosiversioside F

cyclosieversioside F

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Astragaloside A
Price: ￥368.0/100mg ￥578.0/500mg ￥88.0/20mg ￥858.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Astragaloside A
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Astragaloside IV(A)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Astragaloside IV 98%
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Astragaloside A

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