Stigmasterol

Modify Date: 2024-01-02 05:16:06

Stigmasterol Structure
Stigmasterol structure
 Common Name Stigmasterol
CAS Number 83-48-7 Molecular Weight 412.691
Density 1.0±0.1 g/cm3 Boiling Point 501.1±19.0 °C at 760 mmHg
Molecular Formula C29H48O Melting Point 165-167 °C(lit.)
MSDS USA Flash Point 219.4±13.7 °C
Symbol GHS06 GHS08
GHS06, GHS08		 Signal Word Danger

 Use of Stigmasterol


Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

 Names

Name stigmasterol
Synonym More Synonyms

 Stigmasterol Biological Activity

Description Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
Related Catalog
Target

MMP[1]
In Vitro Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1].
Cell Assay A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1].
References

[1]. Gabay O, et al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 501.1±19.0 °C at 760 mmHg
Melting Point 165-167 °C(lit.)
Molecular Formula C29H48O
Molecular Weight 412.691
Flash Point 219.4±13.7 °C
Exact Mass 412.370514
PSA 20.23000
LogP 10.21
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.531
Storage condition 2~8°C
Water Solubility insoluble

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary Statements P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn,Xi
Risk Phrases R22
Safety Phrases S22-S24/25-S36/37
RIDADR UN 1888 6.1/PG 3
WGK Germany 3
HS Code 2906199090

 Synthetic Route

 Customs

HS Code 2906199090
Summary 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles68

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 Synonyms

(24S)-5,22-Stigmastadien-3b-ol
Stigmasta-5,22-dien-3-ol, (3β,22E)-
STIGMASTEROL (STIGMASTERIN)
(24S)-Stigmast-5,22-dien-3β-ol
STIGMASTEROL(P)
Wulzen anti-stiffness factor
Guinea-pig-anti-stiffness factor
SULFISOXAZOLE
Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI)
Stigmasta-5,22-dien-3β-ol
Stigmasterol
δ5,22-Stigmastadien-3β-ol
Anti-stiffness factor
(3β,22E)-Stigmasta-5,22-dien-3-ol
Stigmasta-5,22-dien-3-ol, (3β)-
Stigmasta-5,22-dien-3-ol, (3β,20R,22E,24S)-
MFCD00003630
Stigmasta-5,22-dien-3β-ol (8CI)
Stigmasta-5,22E-dien-3β-ol
isofucosterol
stigmasta-5,22-dien-3-b-ol
Stigmastero
STIGMASTA-5,22-DIEN-3-OL,(3B,22E)-
EINECS 201-482-7
Stigmasterin
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
(3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol
3b-Hydroxy-24-ethyl-D5,22-cholestadiene
δ5-Stigmasterol
24S-ethylcholest-5,22-dien-3β-ol
stigmasta-5,22-dien-3-β-ol
β-Stigmasterol
(24S)-5,22-Stigmastadien-3β-ol
(3b,22E)-Stigmasta-5,22-dien-3-ol
5,22-stigmastadien-3β-ol
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
PHYTOSTEROL
UNII-99WUK5D0Y8
(24S)-24-Ethylcholesta-5,22-dien-3β-ol
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  • Product Name: Stigmasterol
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

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Related Compounds: More...
stigmasterol
4736-55-4
stigmasterol
68555-08-8
stigmasterol
481-16-3
β-stigmasterol
134876-41-8
Stigmasterol-d5-1
2260669-29-0
stigmasterol acetate
53139-42-7
STIGMASTEROL ACETATE
4651-48-3
stigmasterol acetate
54482-54-1
O-TBDMS-stigmasterol
122795-00-0
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