Name | stigmasterol |
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Synonyms |
(24S)-5,22-Stigmastadien-3b-ol
Stigmasta-5,22-dien-3-ol, (3β,22E)- STIGMASTEROL (STIGMASTERIN) (24S)-Stigmast-5,22-dien-3β-ol STIGMASTEROL(P) Wulzen anti-stiffness factor Guinea-pig-anti-stiffness factor SULFISOXAZOLE Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI) Stigmasta-5,22-dien-3β-ol Stigmasterol δ5,22-Stigmastadien-3β-ol Anti-stiffness factor (3β,22E)-Stigmasta-5,22-dien-3-ol Stigmasta-5,22-dien-3-ol, (3β)- Stigmasta-5,22-dien-3-ol, (3β,20R,22E,24S)- MFCD00003630 Stigmasta-5,22-dien-3β-ol (8CI) Stigmasta-5,22E-dien-3β-ol isofucosterol stigmasta-5,22-dien-3-b-ol Stigmastero STIGMASTA-5,22-DIEN-3-OL,(3B,22E)- EINECS 201-482-7 Stigmasterin (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol 3b-Hydroxy-24-ethyl-D5,22-cholestadiene δ5-Stigmasterol 24S-ethylcholest-5,22-dien-3β-ol stigmasta-5,22-dien-3-β-ol β-Stigmasterol (24S)-5,22-Stigmastadien-3β-ol (3b,22E)-Stigmasta-5,22-dien-3-ol 5,22-stigmastadien-3β-ol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol PHYTOSTEROL UNII-99WUK5D0Y8 (24S)-24-Ethylcholesta-5,22-dien-3β-ol |
Description | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
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Related Catalog | |
Target |
MMP[1] |
In Vitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. |
Cell Assay | A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 501.1±19.0 °C at 760 mmHg |
Melting Point | 165-167 °C(lit.) |
Molecular Formula | C29H48O |
Molecular Weight | 412.691 |
Flash Point | 219.4±13.7 °C |
Exact Mass | 412.370514 |
PSA | 20.23000 |
LogP | 10.21 |
Vapour Pressure | 0.0±2.9 mmHg at 25°C |
Index of Refraction | 1.531 |
Storage condition | 2~8°C |
Water Solubility | insoluble |
Symbol |
GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
Precautionary Statements | P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | Xn,Xi |
Risk Phrases | R22 |
Safety Phrases | S22-S24/25-S36/37 |
RIDADR | UN 1888 6.1/PG 3 |
WGK Germany | 3 |
HS Code | 2906199090 |
Precursor 6 | |
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DownStream 10 | |
HS Code | 2906199090 |
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Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |