BioBioPha
China
Product Name: Stigmasterol
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Stigmasterol
Price: ￥198.0/5g ￥658.0/25g ￥108.0/20mg
Purity: 95.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Stigmasterol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Stigmasterol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: stigmasterol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

83-48-7

83-48-7 structure

83-48-7 structure

Name: Stigmasterol
Chemical Name: stigmasterol
CAS Number: 83-48-7
Molecular Formula: C₂₉H₄₈O
Molecular Weight: 412.691
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Thiopyrimidine
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-02 05:16:06
Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

Name	stigmasterol
Synonyms	(24S)-5,22-Stigmastadien-3b-ol Stigmasta-5,22-dien-3-ol, (3β,22E)- STIGMASTEROL (STIGMASTERIN) (24S)-Stigmast-5,22-dien-3β-ol STIGMASTEROL(P) Wulzen anti-stiffness factor Guinea-pig-anti-stiffness factor SULFISOXAZOLE Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI) Stigmasta-5,22-dien-3β-ol Stigmasterol δ5,22-Stigmastadien-3β-ol Anti-stiffness factor (3β,22E)-Stigmasta-5,22-dien-3-ol Stigmasta-5,22-dien-3-ol, (3β)- Stigmasta-5,22-dien-3-ol, (3β,20R,22E,24S)- MFCD00003630 Stigmasta-5,22-dien-3β-ol (8CI) Stigmasta-5,22E-dien-3β-ol isofucosterol stigmasta-5,22-dien-3-b-ol Stigmastero STIGMASTA-5,22-DIEN-3-OL,(3B,22E)- EINECS 201-482-7 Stigmasterin (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol 3b-Hydroxy-24-ethyl-D5,22-cholestadiene δ5-Stigmasterol 24S-ethylcholest-5,22-dien-3β-ol stigmasta-5,22-dien-3-β-ol β-Stigmasterol (24S)-5,22-Stigmastadien-3β-ol (3b,22E)-Stigmasta-5,22-dien-3-ol 5,22-stigmastadien-3β-ol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol PHYTOSTEROL UNII-99WUK5D0Y8 (24S)-24-Ethylcholesta-5,22-dien-3β-ol

Description	Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
Related Catalog	Natural Products >> Steroids Research Areas >> Inflammation/Immunology
Target	MMP[1]
In Vitro	Preincubation of Stigmasterol to IL-1beta-treated cells shows signiﬁcant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1].
Cell Assay	A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1].
References	[1]. Gabay O, et al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16.

Density	1.0±0.1 g/cm3
Boiling Point	501.1±19.0 °C at 760 mmHg
Melting Point	165-167 °C(lit.)
Molecular Formula	C₂₉H₄₈O
Molecular Weight	412.691
Flash Point	219.4±13.7 °C
Exact Mass	412.370514
PSA	20.23000
LogP	10.21
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.531
Storage condition	2~8°C
Water Solubility	insoluble

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary Statements	P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,Xi
Risk Phrases	R22
Safety Phrases	S22-S24/25-S36/37
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
HS Code	2906199090

Precursor 6
122795-00-0 4651-48-3 70813-67-1 53603-94-4
83787-28-4 70813-69-3
DownStream 10
474-63-5 4651-48-3 915-05-9 2364-21-8
83-46-5 83-45-4 10211-88-8 167958-89-6
80731-53-9 32212-73-0

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%