Nefazodone hydrochloride

Modify Date: 2024-01-02 12:38:17

Nefazodone hydrochloride Structure
Nefazodone hydrochloride structure
Common Name Nefazodone hydrochloride
CAS Number 82752-99-6 Molecular Weight 506.46800
Density N/A Boiling Point 599.6ºC at 760 mmHg
Molecular Formula C25H33Cl2N5O2 Melting Point 186-188ºC
MSDS Chinese USA Flash Point 316.4ºC

 Use of Nefazodone hydrochloride


Nefazodone hydrochloride is an antidepressant drug.

 Names

Name nefazodone hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 599.6ºC at 760 mmHg
Melting Point 186-188ºC
Molecular Formula C25H33Cl2N5O2
Molecular Weight 506.46800
Flash Point 316.4ºC
Exact Mass 505.20100
PSA 55.53000
LogP 4.35680
Storage condition Desiccate at RT
Water Solubility DMSO: ~11 mg/mL at 60 °C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Nefazodone HCl
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Nefazodone HCl
CAS number:82752-99-6

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C25H32ClN5O2.ClH
Molecular weight:506.5

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~63%

Nefazodone hydrochloride Structure

Nefazodone hydr...

CAS#:82752-99-6

Literature: Mead Johnson and Company Patent: US4487773 A1, 1984 ; US 4487773 A

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles30

More Articles
Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

The relation between changes in patients' interpersonal impact messages and outcome in treatment for chronic depression.

J. Consult. Clin. Psychol. 80(3) , 354-64, (2012)

Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain ...

Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

Drug Metab. Dispos. 36(6) , 1016-29, (2008)

In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attem...

 Synonyms

MFCD00865396
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one,hydrochloride
Nefazodone Hydrochloride
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