FEN1-IN-C20
Modify Date: 2025-11-28 10:42:41
FEN1-IN-C20 structure
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Common Name | FEN1-IN-C20 | ||
|---|---|---|---|---|
| CAS Number | 824983-94-0 | Molecular Weight | 393.417 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H15N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FEN1-IN-C20FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM; significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin; efficiently suppresses cancer progression in combination with cisplatin in mouse models. |
| Name | FEN1-IN-C20 |
|---|
| Description | FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM; significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin; efficiently suppresses cancer progression in combination with cisplatin in mouse models. |
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| References | References 1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21. 2. He L, et al. Mol Oncol. 2017 Jun;11(6):640-654. 3. He L, et al. EBioMedicine. 2016 Dec;14:32-43. View Related Products by Target Other Targets |
| Molecular Formula | C20H15N3O4S |
|---|---|
| Molecular Weight | 393.417 |
| InChIKey | VQEJSOSSYFEKGH-UHFFFAOYSA-N |
| SMILES | NC(=O)c1ccc(-c2cccc(Cn3c(=O)n(O)c(=O)c4sccc43)c2)cc1 |