1995893-58-7
1995893-58-7 structure
- Name: FEN1-IN-4
- Chemical Name: FEN1-IN-4
- CAS Number: 1995893-58-7
- Molecular Formula: C12H12N2O3
- Molecular Weight: 232.24
- Catalog: Signaling Pathways Others Others
- Create Date: 2020-08-11 16:43:31
- Modify Date: 2024-08-09 19:05:38
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FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1].
| Name | FEN1-IN-4 |
|---|
| Description | FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
hFEN1[1] |
| In Vitro | FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1]. |
| References |
| Molecular Formula | C12H12N2O3 |
|---|---|
| Molecular Weight | 232.24 |