Tetramethylrhodamine-5-isothiocyanate

Modify Date: 2024-01-12 21:14:50

Tetramethylrhodamine-5-isothiocyanate Structure
Tetramethylrhodamine-5-isothiocyanate structure
Common Name Tetramethylrhodamine-5-isothiocyanate
CAS Number 80724-19-2 Molecular Weight 443.51800
Density N/A Boiling Point N/A
Molecular Formula C25H21N3O3S Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Tetramethylrhodamine-5-isothiocyanate


Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles[1][2].

 Names

Name 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-5-isothiocyanatobenzoate
Synonym More Synonyms

 Tetramethylrhodamine-5-isothiocyanate Biological Activity

Description Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles[1][2].
Related Catalog
References

[1]. Alayed KM, et al. Immunostaining for rapid diagnosis of acute promyelocytic leukemia with the tetramethylrhodamine-5-isothiocyanate-conjugated anti-promyelocytic leukemia monoclonal antibody PG-M3. Arch Pathol Lab Med. 2013 Nov;137(11):1669-73.

[2]. Navarro SM, et al. Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days. Ther Deliv. 2014 Nov;5(11):1191-201.

 Chemical & Physical Properties

Molecular Formula C25H21N3O3S
Molecular Weight 443.51800
Exact Mass 443.13000
PSA 104.20000
LogP 4.76390
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22;S24/25
RIDADR NONH for all modes of transport

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 Synonyms

Xanthylium
Tetramethylrhodamine-5-isothiocyanate
5-TRITC
5-TRITC,G isomer
MFCD00467978