Brevetoxin2(PbTx-2)

Modify Date: 2025-08-25 09:32:40

Brevetoxin2(PbTx-2) structure	Common Name	Brevetoxin2(PbTx-2)
	CAS Number	79580-28-2	Molecular Weight	895.08200
	Density	1.188g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₀H₇₀O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Brevetoxin2(PbTx-2)

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Name	brevetoxin b
Synonym	More Synonyms

Description	Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Density	1.188g/cm3
Molecular Formula	C₅₀H₇₀O₁₄
Molecular Weight	895.08200
Exact Mass	894.47700
PSA	155.90000
LogP	5.47210
Index of Refraction	1.522
InChIKey	LYTCVQQGCSNFJU-FGRVLNGBSA-N
SMILES	C=C(C=O)CC1CC(O)C2(C)OC3CC4OC5CC6(C)OC7(C)CCC8OC9CC%10(C)OC%11C(C)=CC(=O)OC%11CC%10OC9CC(C)C8OC7CC6OC5(C)CC=CC4OC3CC2O1

Brevetoxin2(PbTx-2) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XW5886000

CHEMICAL NAME :: Toxin T-34

CAS REGISTRY NUMBER :: 79580-28-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C50-H70-O14

MOLECULAR WEIGHT :: 895.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6600 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Hazard Class	6.1(a)

Brevetoxin-3

CAS#:85079-48-7

Brevetoxin2(PbTx-2)

CAS#:79580-28-2

Literature: Kadota, Isao; Takamura, Hiroyoshi; Nishii, Hiroki; Yamamoto, Yoshinori Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9246 - 9250

Precursor 1
CAS#:85079-48-7 Brevetoxin-3
DownStream 0

brevetoxin-B

gb2

btx-b

PBTX-2

toxint-34

t4-7

GBTX-2

t4-7toxin

gb2toxin

BREVETOXIN 2

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