DC Chemicals Limited
China
Product Name: Brevetoxin B
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Purity: 98.0%
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Contact: Tony Cao

79580-28-2

79580-28-2 structure

Name: Brevetoxin2(PbTx-2)
Chemical Name: brevetoxin b
CAS Number: 79580-28-2
Molecular Formula: C₅₀H₇₀O₁₄
Molecular Weight: 895.08200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2018-09-10 16:32:18
Modify Date: 2024-01-05 11:42:17
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Name	brevetoxin b
Synonyms	brevetoxin-B gb2 btx-b PBTX-2 toxint-34 t4-7 GBTX-2 t4-7toxin gb2toxin BREVETOXIN 2

Description	Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Density	1.188g/cm3
Molecular Formula	C₅₀H₇₀O₁₄
Molecular Weight	895.08200
Exact Mass	894.47700
PSA	155.90000
LogP	5.47210
Index of Refraction	1.522

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XW5886000

CHEMICAL NAME :: Toxin T-34

CAS REGISTRY NUMBER :: 79580-28-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C50-H70-O14

MOLECULAR WEIGHT :: 895.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6600 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Hazard Class	6.1(a)

85079-48-7

79580-28-2

Literature: Kadota, Isao; Takamura, Hiroyoshi; Nishii, Hiroki; Yamamoto, Yoshinori Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9246 - 9250

Precursor 1
85079-48-7
DownStream 0

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