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Brevetoxin2(PbTx-2)

Names

[ CAS No. ]:
79580-28-2

[ Name ]:
Brevetoxin2(PbTx-2)

[Synonym ]:
brevetoxin-B
gb2
btx-b
PBTX-2
toxint-34
t4-7
GBTX-2
t4-7toxin
gb2toxin
BREVETOXIN 2

Biological Activity

[Description]:

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Chemical & Physical Properties

[ Density]:
1.188g/cm3

[ Molecular Formula ]:
C50H70O14

[ Molecular Weight ]:
895.08200

[ Exact Mass ]:
894.47700

[ PSA ]:
155.90000

[ LogP ]:
5.47210

[ Index of Refraction ]:
1.522

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XW5886000
CHEMICAL NAME :
Toxin T-34
CAS REGISTRY NUMBER :
79580-28-2
LAST UPDATED :
198909
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C50-H70-O14
MOLECULAR WEIGHT :
895.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6600 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

Safety Information

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
26/27/28

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 2

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds