Brevetoxin-3
Modify Date: 2024-01-13 16:10:06
Brevetoxin-3 structure
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Common Name | Brevetoxin-3 | ||
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| CAS Number | 85079-48-7 | Molecular Weight | 897.09800 | |
| Density | 1.187g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C50H72O14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Brevetoxin-3Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2]. |
| Name | Brevetoxin 3 |
|---|---|
| Synonym | More Synonyms |
| Description | Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2]. |
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| Related Catalog | |
| Target |
IC50: voltage-gated Na+ channel[1] |
| In Vitro | Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV)[1]. |
| In Vivo | Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues[3]. . Animal Model: Pregnant CD-1 mice[3] Dosage: 2.8 μg/kg Administration: Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 Result: Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |
| References |
| Density | 1.187g/cm3 |
|---|---|
| Molecular Formula | C50H72O14 |
| Molecular Weight | 897.09800 |
| Exact Mass | 896.49200 |
| PSA | 159.06000 |
| LogP | 5.26550 |
| Index of Refraction | 1.52 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | UN 3172 |
|---|---|
| Hazard Class | 6.1(a) |
| Precursor 0 | |
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| DownStream 1 | |
CAS#:79580-28-2| GB 3 toxin |
| T-17 toxin |
| Brevetoxin PbTx 3 |
| PbTx 3 |
| GB 3 |
| [3H]-PbTx 3 |
| Brevetoxin T17 |
| brevetoxin-3 |
| Toxin T-17 |
| Ptychodiscus brevis toxin 3 |