| Description |
JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].
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| Related Catalog |
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| Target |
IC50: 50 nM (hSMOX)[1]; >2 μM (hPAOX and LSD1)[1].
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| In Vitro |
JNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1]. JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].
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| References |
[1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787.
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