JNJ-1661010

Modify Date: 2024-01-04 22:41:14

JNJ-1661010 structure	Common Name	JNJ-1661010
	CAS Number	681136-29-8	Molecular Weight	365.452
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₉N₅OS	Melting Point	240.48 °C
	MSDS	USA	Flash Point	N/A

Use of JNJ-1661010

JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics[1][2].

Name	N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Synonym	More Synonyms

Description	JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> FAAH
Target	IC50: 34 nM (rat FAAH) and 33 nM (human FAAH)[1]
In Vivo	JNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model[2]. JNJ-1661010 (i.p.; 10 mg/kg) has a T1/2 of 35 mins, a CL of 0.032 mL/min/kg, and a Cmax of 1.58 μM for rats[1].
References	[1]. Keith JM, et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43. [2]. Karbarz MJ, et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylicacid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009 Jan;108(1):316-29.

Density	1.3±0.1 g/cm3
Melting Point	240.48 °C
Molecular Formula	C₁₉H₁₉N₅OS
Molecular Weight	365.452
Exact Mass	365.131042
PSA	89.60000
LogP	2.57
Index of Refraction	1.679
Storage condition	Store at +4°C
Water Solubility	DMSO: ≥28mg/mL

3-PHENYL-5-PIPE...

CAS#:306935-14-8

Phenylisocyanate

CAS#:103-71-9

~82%

JNJ-1661010

CAS#:681136-29-8

Literature: Takeda Pharmaceutical Company Limited Patent: EP1813606 A1, 2007 ; Location in patent: Page/Page column 32-33 ;

N/A

CAS#:918135-62-3

Phenylboronic acid

CAS#:98-80-6

JNJ-1661010

CAS#:681136-29-8

Literature: Apodaca, Richard; Breitenbucher, J. Guy; Pattabiraman, Kanaka; Seierstad, Mark; Xiao, Wei Patent: US2007/4741 A1, 2007 ; Location in patent: Page/Page column 11; 14 ;

Precursor 3
CAS#:306935-14-8 3-PHENYL-5-PIPE... CAS#:103-71-9 Phenylisocyanate CAS#:98-80-6 Phenylboronic acid
DownStream 0

N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide

DC Chemicals Limited
China
Product Name: JNJ-1661010
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: JNJ 1661010
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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