JNJ-4355

Modify Date: 2024-01-17 16:44:07

JNJ-4355 structure	Common Name	JNJ-4355
	CAS Number	2697112-32-4	Molecular Weight	760.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₄₃ClFN₅O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ-4355

JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].

Name	JNJ-4355

Description	JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:18 pM (Ki)
In Vitro	JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples[2].
In Vivo	JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].
References	[1]. Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385. [2]. Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.

Molecular Formula	C₄₀H₄₃ClFN₅O₅S
Molecular Weight	760.32