Nestoron
Modify Date: 2024-01-08 14:55:31
Nestoron structure
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Common Name | Nestoron | ||
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| CAS Number | 7759-35-5 | Molecular Weight | 370.48200 | |
| Density | 1.15g/cm3 | Boiling Point | 499.3ºC at 760mmHg | |
| Molecular Formula | C23H30O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 216.2ºC | |
Use of NestoronNestoron(ST1435; Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor. IC50 value:Tareget: progesterone receptorNestorone acts primarily as a high-affinity agonist of the progesterone receptor. It lacks significant affinity for the androgen receptor, and accordingly, does not produce any androgenic or anabolic effects. It does not bind to the estrogen receptor either. Nestorone does however have some affinity for the glucocorticoid receptor, where it appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. Nestorone does not bind to sex hormone-binding globulin, and is instead bound to serum albumin. |
| Name | Nestoron |
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| Synonym | More Synonyms |
| Description | Nestoron(ST1435; Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor. IC50 value:Tareget: progesterone receptorNestorone acts primarily as a high-affinity agonist of the progesterone receptor. It lacks significant affinity for the androgen receptor, and accordingly, does not produce any androgenic or anabolic effects. It does not bind to the estrogen receptor either. Nestorone does however have some affinity for the glucocorticoid receptor, where it appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. Nestorone does not bind to sex hormone-binding globulin, and is instead bound to serum albumin. |
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| Related Catalog | |
| References |
| Density | 1.15g/cm3 |
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| Boiling Point | 499.3ºC at 760mmHg |
| Molecular Formula | C23H30O4 |
| Molecular Weight | 370.48200 |
| Flash Point | 216.2ºC |
| Exact Mass | 370.21400 |
| PSA | 60.44000 |
| LogP | 4.18520 |
| Index of Refraction | 1.549 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
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Nestorone: clinical applications for contraception and HRT.
Steroids 68(10-13) , 907-13, (2003) The 19-nor derivatives of progesterone are referred to as "pure" progestational molecules as they bind almost exclusively to the progesterone receptor (PR) without interfering with receptors of other ... |
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Recent developments in contraceptive implants at the Population Council.
Contraception 65(1) , 113-9, (2002) Development of contraceptive implant methods, when based on established or on new synthetic chemical entities, is a decadal or multi-decadal process. The process often requires the cooperation of nume... |
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Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone.
J. Steroid Biochem. Mol. Biol. 116(1-2) , 15-20, (2009) The aim of the present study was to evaluate the potential action of Nestorone (alone or in combination with estradiol valerate) on the level of allopregnanolone and of the opioid beta-endorphin in se... |
| NESTORONE |
| 19-Norpregn-4-ene-3,20-dione,17-hydroxy-16-methylene-,acetate |
| 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate |
| 17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE |
| 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate |
| Elcometrine |