醋酸烯诺孕酮

更新时间：2024-01-08 14:55:31

醋酸烯诺孕酮结构式	常用名	醋酸烯诺孕酮	英文名	Nestoron
	CAS号	7759-35-5	分子量	370.48200
	密度	1.15g/cm3	沸点	499.3ºC at 760mmHg
	分子式	C₂₃H₃₀O₄	熔点	N/A
	MSDS	中文版美版	闪点	216.2ºC

醋酸烯诺孕酮用途

Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。

中文名	醋酸烯诺孕酮
英文名	Nestoron
英文别名	更多

描述	Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。
相关类别	信号通路 >> 其他 >> 孕激素受体研究领域 >> 内分泌天然产物 >> 类固醇
参考文献	[1]. Ilani N, et al. A New Combination of Testosterone and Nestorone Transdermal Gels for Male Hormonal Contraception.J Clin Endocrinol Metab. 2012 Jul 12. [2]. Rad M, et al. Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE.Contraception. 2012 Sep;86(3):231-7. Epub 2012 Mar 23 [3]. Hussain R, et al. Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.Endocrinology. 2011 Oct;152(10):3820-31. Epub 2011 Aug 9. [4]. Prasad PV, et al. Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive.Steroids. 2010 Mar;75(3):252-64. Epub 2010 Jan 11. [5]. Elsimar M Coutinho et al. Use of a single implant of elcometrine (ST-1435), a nonorally active progestin, as a long acting contraceptive for postpartum nursing women Contraception Volume 59, Issue 2, February 1999, Pages 115-122

描述

Nestoron(ST1435; Elcometrine)是19-norprogesterone衍生物,是孕酮受体高亲和力激动剂。

相关类别

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

天然产物 >> 类固醇

参考文献

[1]. Ilani N, et al. A New Combination of Testosterone and Nestorone Transdermal Gels for Male Hormonal Contraception.J Clin Endocrinol Metab. 2012 Jul 12.

[2]. Rad M, et al. Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE.Contraception. 2012 Sep;86(3):231-7. Epub 2012 Mar 23

[3]. Hussain R, et al. Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.Endocrinology. 2011 Oct;152(10):3820-31. Epub 2011 Aug 9.

[4]. Prasad PV, et al. Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive.Steroids. 2010 Mar;75(3):252-64. Epub 2010 Jan 11.

[5]. Elsimar M Coutinho et al. Use of a single implant of elcometrine (ST-1435), a nonorally active progestin, as a long acting contraceptive for postpartum nursing women Contraception Volume 59, Issue 2, February 1999, Pages 115-122

密度	1.15g/cm3
沸点	499.3ºC at 760mmHg
分子式	C₂₃H₃₀O₄
分子量	370.48200
闪点	216.2ºC
精确质量	370.21400
PSA	60.44000
LogP	4.18520
折射率	1.549
储存条件	2-8℃

醋酸烯诺孕酮毒性英文版

危险品运输编码	NONH for all modes of transport

Nestorone: clinical applications for contraception and HRT.

Steroids 68(10-13) , 907-13, (2003)

The 19-nor derivatives of progesterone are referred to as "pure" progestational molecules as they bind almost exclusively to the progesterone receptor (PR) without interfering with receptors of other ...

Recent developments in contraceptive implants at the Population Council.

Contraception 65(1) , 113-9, (2002)

Development of contraceptive implant methods, when based on established or on new synthetic chemical entities, is a decadal or multi-decadal process. The process often requires the cooperation of nume...

Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone.

J. Steroid Biochem. Mol. Biol. 116(1-2) , 15-20, (2009)

The aim of the present study was to evaluate the potential action of Nestorone (alone or in combination with estradiol valerate) on the level of allopregnanolone and of the opioid beta-endorphin in se...

NESTORONE

19-Norpregn-4-ene-3,20-dione,17-hydroxy-16-methylene-,acetate

16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate

17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE

17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate

Elcometrine